association of ccr5-59029 a/g and ccr2-v64i variants with renal allograft survival

نویسندگان

mir davood omrani

department of genetics mohammad reza mokhtari

department of urology and nephrology, uromia university of medical science, uromia, iran ali tagizadae

department of urology and nephrology, uromia university of medical science, uromia, iran morteza bagheri

department of genetics pedram ahmad-poor

چکیده

background: despite advances in the medical care of renal transplant recipients which have led to an improvement in allograft survival, renal allograft rejection is still a major ob-stacle to successful organ transplantation. understanding the mechanisms contributing to allograft rejection will be of great importance for the development of efficient antirejection strategies. objective: the aim of current investigation was to study the impact of polymor-phisms of ccr5δ32, ccr5- 59029 a/g and ccr2-v64i on renal allograft survival. methods: using pcr and pcr-rflp methods in 84 renal transplant recipients, the influ-ence of ccr5δ32, ccr5- 59029 a/g and ccr2-v64i polymorphisms on renal allograft survival in two rejector and non-rejector groups were examined. rejector group was de-fined as having rejection before 1 year and non-rejector group had stable graft function at least for 5 years. results: significant reductions were found in the risk of renal transplant rejection in recipients possessing the ccr2-64i (a) allele (p=0.03) or 59029-a allele (p=0.03) compared to non-rejector group. there were no significant differences in the fre-quency of ccr5δ32 polymorphism in rejector group compared to non-rejector group (p>0.05). conclusion: it was possible to conclude that the chemokine receptors ccr2-v64i (a) and ccr5- 59029 a alleles may influence renal allograft survival.

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Association of CCR5-59029 A/G and CCR2-V64I Variants with Renal Allograft Survival

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عنوان ژورنال:
iranian journal of immunology

جلد ۵، شماره ۴، صفحات ۲۰۱-۲۰۶

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